Disable windows hot key

You can disable all built-in Windows hotkeys except Win+L and Win+U by making the following change to the registry.You may need to reboot after changing the registry value.

First,Open registry. Run|regedit

Browse to this nodes

HKEY_CURRENT_USER\Software\Microsoft\Windows\CurrentVersion
\Policies\Explorer

Create a new DWORD value
Title:NoWinKeys
Value:1